Anne-Marie M. OswaldBSc Biology, Simon Fraser University
PhD Neuroscience, University of Ottawa Postdoctoral Research Center for Neural Science, New York University Biological Sciences, Carnegie Mellon University Faculty Positions Assistant, Associate Professor, Department of Neuroscience, University of Pittsburgh (2012-2020) Associate Professor, Department of Neurobiology, University of Chicago (present) |
Background |
Most of my research has been driven by the quest to understand the relationship between synaptic dynamics and spike activity. My doctoral work in the laboratory of Leonard Maler focused on coding of behaviorally relevant electrosensory stimuli in patterns of spike activity. This work left me questioning how these patterns were transformed as they passed through synapses within and between brain areas. During my first postdoc in the laboratory of Alex Reyes (NYU) I investigated cellular and synaptic properties as well as patterns of connectivity between neurons in auditory cortex. We found that circuit motifs and synaptic properties combine to influence network responses within auditory cortex. However, my ultimate desire to understand how neural activity transfers information between brain areas lead me to the olfactory system. During my second postdoc in Nathan Urban's lab (CMU) I found that short term synaptic dynamics at M/T synapses onto pyramidal cells influence the transfer of information contained in spike trains between the olfactory bulb and cortex. When I started my own lab at the University of Pittsburgh, I decided to focus on inhibitory circuitry. In particular, we investigated the circuitry responsible for inhibition, disinhibition and gating excitatory synaptic plasticity in piriform cortex. In 2021 the laboratory moved to the Neuroscience Institute and the University of Chicago. We are now focusing on how circuit plasticity (both excitatory and inhibitory) underlie changes in spike activity, and assembly formation during novel odor processing and olfactory learning. Check out our research page to learn more.
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Publications |
M Canto-Bustos, FK Friason, C Bassi and AM Oswald (2022) Disinhibitory circuitry gates associative plasticity at recurrent synapses between cortical pyramidal neurons. J.Neuroscience, 42 (14), 2942-2950 -very honored to have been selected as a paper for Journal Club in J. Neuroscience AM Oswald, Srdjan Ostojic, Curating more diverse scientific conferences. (2020) Nature Reviews Neuroscience https://doi.org/10.1038/s41583-020-0373-4-Invited commentary MC Chiang, EK Nguyen, MB Canto-Bustos, AE Papale, AM Oswald and SE Ross (2020) Divergent Neural Pathways Emanating from the Lateral Parabrachial Nucleus Mediate Distinct Components of the Pain Response Neuron 106: 927-939 AM Large, NW Vogler, M Canto-Bustos, FK Friason, P Schick and AM Oswald (2018) Differential inhibition of pyramidal cells and inhibitory interneurons along the rostrocaudal axis of anterior piriform cortex Proc Natl Acad Sci U S A. 115 (34) E8067-E8076 AM Large, NA Kunz, SL Mielo, AM Oswald (2016) Inhibition by somatostatin interneurons in olfactory cortex. Front. Neural Circuits | doi: 10.3389/fncir.2016.00062 AM Large, NW Vogler, S Mielo, AM Oswald (2016) Balanced feedforward inhibition and dominant recurrent inhibition in olfactory cortex. Proc Natl Acad Sci U S A. 113(8):2276-81. AM Oswald, NN Urban (2012) There and Back Again: The Corticobulbar Loop. Neuron. 76:1045-47 -Preview article of Markopolous et al. 2012 and Boyd et al., 2012 in the same issue. AM Oswald, NN Urban (2012) Interactions between behaviorally relevant rhythms and synaptic plasticity alter coding in the piriform cortex. J. Neuroscience. 32: 6092-6104. AL Kumar, AM Oswald, NN Urban, B Doiron (2011) Shaping neural correlation through balanced synaptic inputs. PLoS Computational Biology. 7(12):e1002305. AM Oswald, AD Reyes (2011) Development of inhibitory timescales in auditory cortex. Cerebral Cortex 21: 1351-1361. AM Oswald*, B Doiron*, J Rinzel, AD Reyes. (2009) Spatial profile and differential recruitment of GABAB modulate oscillatory activity in auditory cortex. J. Neuroscience. 29(33):10321-34 AM Oswald, AD Reyes (2008) Maturation of the intrinsic and synaptic properties of L2/3 pyramidal neurons in mouse auditory cortex. J. Neurophysiology, 99:2998-3008. AM Oswald, B Doiron, L Maler (2007) Interval Coding I: Burst interspike intervals as indicators of stimulus intensity. J. Neurophysiology 97: 2731-2743 -Editorial Focus, J.Neurophysiology 97: 2577-2578 B Doiron, AM Oswald, L Maler (2007) Interval Coding II: Dendrite dependent mechanisms. J. Neurophysiology 97: 2744-2757 -Editorial Focus, J.Neurophysiology 97: 2577-2578 AM Oswald, ML Schiff, AD Reyes. (2006) Synaptic mechanisms underlying auditory processing. Current Opinion in Neurobiology 16(4): 371-376 AM Oswald, MJ Chacron, B Doiron, J Bastian, L Maler. (2004) Parallel processing of sensory input by bursts and isolated spikes. Journal of Neuroscience 24 (18): 4351-4362 -Featured in “This Week in the Journal”, Journal of Neuroscience 24 (18) AM Oswald, JE Lewis and L Maler. (2002) Dynamically interacting processes underlie synaptic plasticity in a feedback pathway. Journal of Neurophysiology 87:2450-63 |