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"Disinhibitory circuitry gates associative plasticity at recurrent synapses between cortical pyramidal neurons."
M Canto-Bustos, FK Friason, C Bassi and A-MM Oswald
Journal of Neuroscience (2022) 42 (14), 2942-2950

We investigated the role of three classes of inhibitory interneurons- Somatostatin (SOM), Parvalbumin (PV) and Vasoactive Intestinal Peptide (VIP), in associative synaptic plasticity at recurrent excitatory synapses between pyramidal neurons in piriform cortex. We find that recruitment of SOM and PV interneurons inhibits associative synaptic plasticity.  Conversely the activation of VIP interneurons promotes synaptic plasticity.  We show that VIP interneurons inhibit SOM interneurons to dishinhibit pyramidal neurons to permit synaptic plasticity.  This could be a key circuit that gates assembly formation in the piriform cortex.
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  • Home
  • Research
    • Circuit Structure pubs
    • Circuits Function Publications
    • Circuits and Behavior
  • People
    • AM Oswald
    • Postdoctoral
    • Graduate Students
    • Undergraduates
  • Publications
  • Events