"Balanced feedforward inhibition and dominant recurrent inhibition in olfactory cortex"
AM Large, NW Vogler, S Mielo and A-MM Oswald
Proc Natl Acad Sci U S A. 113(8):2276-81
We investigated the relationship between excitation and inhibition onto the three main classes of excitatory neuron in the anterior piriform cortex. Our main finding is that all cell types receive balanced feedforward excitation and inhibition while recurrent inhibition is much stronger than excitation. We also found that superficial L2 neurons (semilunar and pyramidal cells) receive less overall inhibition that deep L3 pyramidal cells. But L2 neurons receive more reliable feedforward inputs than L3 neurons. This suggests that these groups of neurons make different contributions to afferent versus recurrent network processing of odor information.
AM Large, NW Vogler, S Mielo and A-MM Oswald
Proc Natl Acad Sci U S A. 113(8):2276-81
We investigated the relationship between excitation and inhibition onto the three main classes of excitatory neuron in the anterior piriform cortex. Our main finding is that all cell types receive balanced feedforward excitation and inhibition while recurrent inhibition is much stronger than excitation. We also found that superficial L2 neurons (semilunar and pyramidal cells) receive less overall inhibition that deep L3 pyramidal cells. But L2 neurons receive more reliable feedforward inputs than L3 neurons. This suggests that these groups of neurons make different contributions to afferent versus recurrent network processing of odor information.